Which of the following would cause the oxy-hemoglobin dissociation curve to shift to the right?

  # Which of the following would cause the oxy-hemoglobin dissociation curve to shift to the right?

 A. Decreased pCO2

B. Increased pH

C. Increased levels of 2,3-DPG

D. Decreased body temperature

The correct answer is C. Increased levels of 2,3-DPG.

The oxy-hemoglobin dissociation curve represents the relationship between the partial pressure of oxygen (pO₂) and hemoglobin's oxygen saturation. A right shift in the curve indicates a decreased affinity of hemoglobin for oxygen, meaning oxygen is more readily released to tissues.

• C. Increased levels of 2,3-DPG (2,3-diphosphoglycerate): Increased 2,3-DPG levels, often seen in conditions like hypoxia or high altitude, reduce hemoglobin's affinity for oxygen, promoting oxygen release to tissues. This causes a right shift in the curve.

Other options:

• A. Decreased pCO₂: This would shift the curve to the left (Bohr effect), as lower carbon dioxide levels increase hemoglobin's oxygen affinity.
• B. Increased pH: Higher pH (more alkaline conditions) also shifts the curve to the left, increasing oxygen affinity.
• D. Decreased body temperature: Lower temperatures shift the curve to the left, as hemoglobin holds onto oxygen more tightly.